Although most people who take Suboxone as directed by their physician are not likely to overdose on this long-acting partial opioid agonist, mixing the drug with other substances – especially other opioids, alcohol, or benzodiazepines – increases its bioavailability to the opioid receptors. This amplifies intoxication as well as the risk of overdose.
Signs of an overdose on Suboxone include:
- Slowed heart rate
 - Tension, anxiety, or irritability
 - Loss of physical coordination
 
- Sleepiness
 - Trouble concentrating
 - Nausea
 
- Seizures
 - Stomach pain
 - Depressed breathing
 
If a person is overdosing on any opioid or Suboxone, call 911 immediately. The individual needs emergency medical treatment.